Surgery Websites
Tang Lab »  People »  Postdoctoral Fellows »  Patrick Ho, Ph.D.

Patrick Ho, Ph.D.

Postdoctoral Scholar

Contact Information

patrick.ho@ucsf.edu
Open Popup

University of California, Los Angeles, Los Angeles, California, Ph.D., Chemical Engineering, 2019

Northwestern University, Evanston, Illinois, M.S., Biotechnology, 2013

University of California, Los Angeles, Los Angeles, California, B.S., Chemical Engineering, 2011

  • University of California, San Francisco, San Francisco, California, Postdoctoral Scholar (co-advised by Jeff Bluestone & Qizhi Tang), since 2019
  • Autoimmumity
  • Cancer Immunology
  • Cell-based Immunotherapy
  • Synthetic Biology

Patrick earned his B.S. in Chemical Engineering at UCLA and his M.S. in Biotechnology at Northwestern University. He then returned to UCLA to receive doctoral training under Dr. Yvonne Chen, focusing his research on reprogramming CD8 T cells to interrogate intracellular disease signatures prior to triggering target-cell lysis. By replacing endogenous lytic granule payloads with engineered granzyme B-based cytotoxic switches that are selectively activated by target intracellular antigens, his dissertation work aimed to expand the repertoire of targetable disease markers and reduce the risk of on-target, off-tumor toxicities for adoptive T-cell therapies.

As a postdoc in the labs of Dr. Jeff Bluestone and Dr. Qizhi Tang, Patrick is applying synthetic biology approaches to engineer regulatory T cells that resist epigenetic reprogramming and retain superior suppressive capacity under destabilizing conditions.

Data provided by UCSF Profiles, powered by CTSI
  1. Ho P, Chen YY. Mammalian synthetic biology in the age of genome editing and personalized medicine. Curr Opin Chem Biol. 2017 Oct; 40:57-64. View in PubMed
  2. Ho P, Ede C, Chen YY. Modularly Constructed Synthetic Granzyme B Molecule Enables Interrogation of Intracellular Proteases for Targeted Cytotoxicity. ACS Synth Biol. 2017 08 18; 6(8):1484-1495. View in PubMed
  1. Ho, P.*, Ede, C., & Chen, Y.Y. COVERT T Cells: Engineering T cells to Interrogate Intracellular Antigens. (Oral Presentation). UCLA I3T Seminar Series: Research In Progress, 10/09/2018.
  2. Ho, P.*, Ede, C., & Chen, Y.Y. COVERT T Cells: Engineering T Cells to Interrogate Intracellular Antigens. (Oral Presentation). ImmunologyLA 2018, 06/15/2018.
  3. Ho, P.*, Ede, C., & Chen, Y.Y. COVERT T Cells: Engineering T Cells to Interrogate Intracellular Antigens. (Oral Presentation). Mammalian Synthetic Biology Workshop 5.0, 05/05/2018.
  4. Ho, P.*, Ede, C., & Chen, Y.Y. COVERT T Cells: Engineering T Cells to Interrogate Intracellular Antigens. (Oral Presentation). Keystone Symposia, Emerging Cellular Therapies: T Cells and Beyond, 02/12/2018.
  5. Ho, P.*, Ede, C., & Chen, Y.Y. COVERT T Cells: Engineering T Cells to Interrogate Intracellular Antigens. (Poster). Keystone Symposia, Emerging Cellular Therapies: T Cells and Beyond, 02/12/2018.
  6. Ho, P.*, Ede, C., & Chen, Y.Y. COVERT Cancer Therapeutics: Engineering T Cells to Target the Untargetable. (Oral Presentation). UCLA-NIH Biotechnology Symposium 2017, 07/14/2017.
  7. Ho, P.*, Ede, C., & Chen, Y.Y. COVERT Cancer Therapeutics: Engineering T Cells to Target the Untargetable. (Oral Presentation). UCLA CBE 4th-year Symposium, 05/19/2017.
  8. Ho, P.*, Ede, C., & Chen, Y.Y. Designing Targeted Therapeutics to Interrogate Intracellular Tumor Antigens. (Oral Presentation). ACS 253rd National Meeting, 04/04/2017.
  9. Ho, P.* & Chen, Y.Y. COVERT Cancer Therapeutics: Engineering T Cells to Interrogate Intracellular Tumor Antigens. (Oral Presentation). UCLA-NIH Biotechnology Symposium 2016, 06/02/2016.
  10. Ho, P.* & Chen, Y.Y. COVERT Cancer Therapeutics: Engineering T Cells to Interrogate Intracellular Tumor Antigens. (Oral Presentation). AIChE 2015 Annual Meeting, 11/12/2015.
  11. Ho, P., Lin, J.L.*, & Wheeldon, I. Engineering Lipid Droplet Targeting Domains in S. Cerevisiae. (Poster). AIChE 2013 Annual Meeting, 11/06/2013.
View all
  1. Ho, P.* and Chen, Y.Y. "Synthetic Biology in Immunotherapy." Synthetic Biology, edited by Christina Smolke, vol. 8, Wiley-VCH, 2018, pp. 349–372.

 

Site Directory
    X